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Incomplete Coverage of Candidate Genes: A Poorly Considered Bias

Current genetic investigations are performed both on the basis of a rational and biologically based choice of candidate genes and through genome wide scans. Nonetheless, lack of replication is a common problem in psychiatric genetics as well as in other genetic fields. There are a number of reasons...

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Detalles Bibliográficos
Autores principales: Drago, Antonio, De Ronchi, Diana, Serretti, Alessandro
Formato: Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd. 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647155/
https://www.ncbi.nlm.nih.gov/pubmed/19412419
http://dx.doi.org/10.2174/138920207783591681
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author Drago, Antonio
De Ronchi, Diana
Serretti, Alessandro
author_facet Drago, Antonio
De Ronchi, Diana
Serretti, Alessandro
author_sort Drago, Antonio
collection PubMed
description Current genetic investigations are performed both on the basis of a rational and biologically based choice of candidate genes and through genome wide scans. Nonetheless, lack of replication is a common problem in psychiatric genetics as well as in other genetic fields. There are a number of reasons for this inconsistency, among them a well known but poorly considered issue is gene coverage. The aim of the present paper is to focus on this well known and defectively deemed bias, especially when a candidate gene approach is chosen. The rational and the technical feasibility of this proposal are discussed as well as a survey of current investigations. The known consistent methodology to fix this bias is also discussed.
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spelling pubmed-26471552009-04-30 Incomplete Coverage of Candidate Genes: A Poorly Considered Bias Drago, Antonio De Ronchi, Diana Serretti, Alessandro Curr Genomics Article Current genetic investigations are performed both on the basis of a rational and biologically based choice of candidate genes and through genome wide scans. Nonetheless, lack of replication is a common problem in psychiatric genetics as well as in other genetic fields. There are a number of reasons for this inconsistency, among them a well known but poorly considered issue is gene coverage. The aim of the present paper is to focus on this well known and defectively deemed bias, especially when a candidate gene approach is chosen. The rational and the technical feasibility of this proposal are discussed as well as a survey of current investigations. The known consistent methodology to fix this bias is also discussed. Bentham Science Publishers Ltd. 2007-11 /pmc/articles/PMC2647155/ /pubmed/19412419 http://dx.doi.org/10.2174/138920207783591681 Text en ©2007 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/) which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Drago, Antonio
De Ronchi, Diana
Serretti, Alessandro
Incomplete Coverage of Candidate Genes: A Poorly Considered Bias
title Incomplete Coverage of Candidate Genes: A Poorly Considered Bias
title_full Incomplete Coverage of Candidate Genes: A Poorly Considered Bias
title_fullStr Incomplete Coverage of Candidate Genes: A Poorly Considered Bias
title_full_unstemmed Incomplete Coverage of Candidate Genes: A Poorly Considered Bias
title_short Incomplete Coverage of Candidate Genes: A Poorly Considered Bias
title_sort incomplete coverage of candidate genes: a poorly considered bias
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647155/
https://www.ncbi.nlm.nih.gov/pubmed/19412419
http://dx.doi.org/10.2174/138920207783591681
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