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Structural and Functional Determinants of γ-Secretase, an Intramembrane Protease Implicated in Alzheimer’s Disease
Alzheimer’s disease is the most common form of neurodegenerative diseases in humans, characterized by the progressive accumulation and aggregation of amyloid-β peptides (Aβ) in brain regions subserving memory and cognition. These 39-43 amino acids long peptides are generated by the sequential proteo...
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| Formato: | Texto |
| Lenguaje: | English |
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Bentham Science Publishers Ltd.
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647162/ https://www.ncbi.nlm.nih.gov/pubmed/19415127 http://dx.doi.org/10.2174/138920207783769521 |