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The Clinical Usefulness of (18)F-FDG PET/CT for the Evaluation of Lymph Node Metastasis in Periorbital Malignancies

OBJECTIVE: The aim of this study was to assess the clinical role of (18)F-FDG PET/CT for the evaluation of lymph node metastasis in periorbital malignancies, compared with CT alone. MATERIALS AND METHODS: We analyzed eighteen PET/CT and CT scans in 15 patients with biopsy-proven periorbital malignan...

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Autores principales: Baek, Chung-Hwan, Chung, Man Ki, Jeong, Han-Sin, Son, Young-Ik, Choi, Jeesun, Kim, Yoon-Duck, Choi, Joon Young, Kim, Hyung-Jin, Ko, Young Hyeh
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Radiology 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647179/
https://www.ncbi.nlm.nih.gov/pubmed/19182496
http://dx.doi.org/10.3348/kjr.2009.10.1.1
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author Baek, Chung-Hwan
Chung, Man Ki
Jeong, Han-Sin
Son, Young-Ik
Choi, Jeesun
Kim, Yoon-Duck
Choi, Joon Young
Kim, Hyung-Jin
Ko, Young Hyeh
author_facet Baek, Chung-Hwan
Chung, Man Ki
Jeong, Han-Sin
Son, Young-Ik
Choi, Jeesun
Kim, Yoon-Duck
Choi, Joon Young
Kim, Hyung-Jin
Ko, Young Hyeh
author_sort Baek, Chung-Hwan
collection PubMed
description OBJECTIVE: The aim of this study was to assess the clinical role of (18)F-FDG PET/CT for the evaluation of lymph node metastasis in periorbital malignancies, compared with CT alone. MATERIALS AND METHODS: We analyzed eighteen PET/CT and CT scans in 15 patients with biopsy-proven periorbital malignancies. We compared the diagnostic capabilities of PET/CT and CT with regard to nodal metastasis by level-by-level analysis and by N staging prediction. The reference standards were surgical pathology (n = 7) from dissected lymph node specimens and the results from radiological follow-up (n = 11, mean 20.5 months; range 10-52 months). Moreover, any changes in patient care as prompted by PET/CT were recorded and compared with treatment planning for CT alone. RESULTS: PET/CT had a sensitivity of 100%, while CT had a sensitivity of 57% (p = 0.03) for nodal metastasis by level-by-level analysis. PET/CT had a specificity of 97%, positive predictive value of 93%, negative predictive value of 100%, and diagnostic accuracy of 98%, while the CT values for these same parameters were 97%, 89%, 82%, and 84%, respectively. PET/CT correctly predicted N staging with an accuracy of 100%, while CT was only 83% accurate (p = 0.01). Regarding the impact on patient care, the extent of surgery for regional lymph nodes and the treatment decision were modified by PET/CT in 39% of patients. CONCLUSION: PET/CT could provide useful information in the management of regional lymph node metastases in patients with periorbital malignancies.
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spelling pubmed-26471792009-02-25 The Clinical Usefulness of (18)F-FDG PET/CT for the Evaluation of Lymph Node Metastasis in Periorbital Malignancies Baek, Chung-Hwan Chung, Man Ki Jeong, Han-Sin Son, Young-Ik Choi, Jeesun Kim, Yoon-Duck Choi, Joon Young Kim, Hyung-Jin Ko, Young Hyeh Korean J Radiol Original Article OBJECTIVE: The aim of this study was to assess the clinical role of (18)F-FDG PET/CT for the evaluation of lymph node metastasis in periorbital malignancies, compared with CT alone. MATERIALS AND METHODS: We analyzed eighteen PET/CT and CT scans in 15 patients with biopsy-proven periorbital malignancies. We compared the diagnostic capabilities of PET/CT and CT with regard to nodal metastasis by level-by-level analysis and by N staging prediction. The reference standards were surgical pathology (n = 7) from dissected lymph node specimens and the results from radiological follow-up (n = 11, mean 20.5 months; range 10-52 months). Moreover, any changes in patient care as prompted by PET/CT were recorded and compared with treatment planning for CT alone. RESULTS: PET/CT had a sensitivity of 100%, while CT had a sensitivity of 57% (p = 0.03) for nodal metastasis by level-by-level analysis. PET/CT had a specificity of 97%, positive predictive value of 93%, negative predictive value of 100%, and diagnostic accuracy of 98%, while the CT values for these same parameters were 97%, 89%, 82%, and 84%, respectively. PET/CT correctly predicted N staging with an accuracy of 100%, while CT was only 83% accurate (p = 0.01). Regarding the impact on patient care, the extent of surgery for regional lymph nodes and the treatment decision were modified by PET/CT in 39% of patients. CONCLUSION: PET/CT could provide useful information in the management of regional lymph node metastases in patients with periorbital malignancies. The Korean Society of Radiology 2009 2009-02-05 /pmc/articles/PMC2647179/ /pubmed/19182496 http://dx.doi.org/10.3348/kjr.2009.10.1.1 Text en Copyright © 2009 The Korean Society of Radiology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Baek, Chung-Hwan
Chung, Man Ki
Jeong, Han-Sin
Son, Young-Ik
Choi, Jeesun
Kim, Yoon-Duck
Choi, Joon Young
Kim, Hyung-Jin
Ko, Young Hyeh
The Clinical Usefulness of (18)F-FDG PET/CT for the Evaluation of Lymph Node Metastasis in Periorbital Malignancies
title The Clinical Usefulness of (18)F-FDG PET/CT for the Evaluation of Lymph Node Metastasis in Periorbital Malignancies
title_full The Clinical Usefulness of (18)F-FDG PET/CT for the Evaluation of Lymph Node Metastasis in Periorbital Malignancies
title_fullStr The Clinical Usefulness of (18)F-FDG PET/CT for the Evaluation of Lymph Node Metastasis in Periorbital Malignancies
title_full_unstemmed The Clinical Usefulness of (18)F-FDG PET/CT for the Evaluation of Lymph Node Metastasis in Periorbital Malignancies
title_short The Clinical Usefulness of (18)F-FDG PET/CT for the Evaluation of Lymph Node Metastasis in Periorbital Malignancies
title_sort clinical usefulness of (18)f-fdg pet/ct for the evaluation of lymph node metastasis in periorbital malignancies
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647179/
https://www.ncbi.nlm.nih.gov/pubmed/19182496
http://dx.doi.org/10.3348/kjr.2009.10.1.1
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