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Structural studies of type I topoisomerases
Topoisomerases are ubiquitous proteins found in all three domains of life. They change the topology of DNA via transient breaks on either one or two of the DNA strands to allow passage of another single or double DNA strand through the break. Topoisomerases are classified into two types: type I enzy...
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Formato: | Texto |
Lenguaje: | English |
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Oxford University Press
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647283/ https://www.ncbi.nlm.nih.gov/pubmed/19106140 http://dx.doi.org/10.1093/nar/gkn1009 |
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author | Baker, Nicole M. Rajan, Rakhi Mondragón, Alfonso |
author_facet | Baker, Nicole M. Rajan, Rakhi Mondragón, Alfonso |
author_sort | Baker, Nicole M. |
collection | PubMed |
description | Topoisomerases are ubiquitous proteins found in all three domains of life. They change the topology of DNA via transient breaks on either one or two of the DNA strands to allow passage of another single or double DNA strand through the break. Topoisomerases are classified into two types: type I enzymes cleave one DNA strand and pass either one or two DNA strands through the break before resealing it, while type II molecules cleave both DNA strands in concert and pass another double strand through the break followed by religation of the double strand break. Here we review recent work on the structure of type I enzymes. These structural studies are providing atomic details that, together with the existing wealth of biochemical and biophysical data, are bringing our understanding of the mechanism of action of these enzymes to the atomic level. |
format | Text |
id | pubmed-2647283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-26472832009-03-04 Structural studies of type I topoisomerases Baker, Nicole M. Rajan, Rakhi Mondragón, Alfonso Nucleic Acids Res Survey and Summary Topoisomerases are ubiquitous proteins found in all three domains of life. They change the topology of DNA via transient breaks on either one or two of the DNA strands to allow passage of another single or double DNA strand through the break. Topoisomerases are classified into two types: type I enzymes cleave one DNA strand and pass either one or two DNA strands through the break before resealing it, while type II molecules cleave both DNA strands in concert and pass another double strand through the break followed by religation of the double strand break. Here we review recent work on the structure of type I enzymes. These structural studies are providing atomic details that, together with the existing wealth of biochemical and biophysical data, are bringing our understanding of the mechanism of action of these enzymes to the atomic level. Oxford University Press 2009-02 2008-12-23 /pmc/articles/PMC2647283/ /pubmed/19106140 http://dx.doi.org/10.1093/nar/gkn1009 Text en © 2008 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Survey and Summary Baker, Nicole M. Rajan, Rakhi Mondragón, Alfonso Structural studies of type I topoisomerases |
title | Structural studies of type I topoisomerases |
title_full | Structural studies of type I topoisomerases |
title_fullStr | Structural studies of type I topoisomerases |
title_full_unstemmed | Structural studies of type I topoisomerases |
title_short | Structural studies of type I topoisomerases |
title_sort | structural studies of type i topoisomerases |
topic | Survey and Summary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647283/ https://www.ncbi.nlm.nih.gov/pubmed/19106140 http://dx.doi.org/10.1093/nar/gkn1009 |
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