Phototoxic aptamers selectively enter and kill epithelial cancer cells

The majority of cancers arise from malignant epithelial cells. We report the design of synthetic oligonucleotides (aptamers) that are only internalized by epithelial cancer cells and can be precisely activated by light to kill such cells. Specifically, phototoxic DNA aptamers were selected to bind t...

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Detalles Bibliográficos
Autores principales: Ferreira, Cátia S. M., Cheung, Melissa C., Missailidis, Sotiris, Bisland, Stuart, Gariépy, Jean
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647295/
https://www.ncbi.nlm.nih.gov/pubmed/19103663
http://dx.doi.org/10.1093/nar/gkn967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647295/
https://www.ncbi.nlm.nih.gov/pubmed/19103663
http://dx.doi.org/10.1093/nar/gkn967

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