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Bacterial topoisomerase I as a target for discovery of antibacterial compounds
Bacterial topoisomerase I is a potential target for discovery of new antibacterial compounds. Mutant topoisomerases identified by SOS induction screening demonstrated that accumulation of the DNA cleavage complex formed by type IA topoisomerases is bactericidal. Characterization of these mutants of...
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| Formato: | Texto |
| Lenguaje: | English |
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Oxford University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647297/ https://www.ncbi.nlm.nih.gov/pubmed/19042977 http://dx.doi.org/10.1093/nar/gkn936 |