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Reactive oxygen species regulate DNA copy number in isolated yeast mitochondria by triggering recombination-mediated replication

Mitochondrial DNA (mtDNA) encodes proteins that are essential for cellular ATP production. Reactive oxygen species (ROS) are respiratory byproducts that damage mtDNA and other cellular components. In Saccharomyces cerevisiae, the oxidized base excision-repair enzyme Ntg1 introduces a double-stranded...

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Detalles Bibliográficos
Autores principales:	Hori, Akiko, Yoshida, Minoru, Shibata, Takehiko, Ling, Feng
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647299/ https://www.ncbi.nlm.nih.gov/pubmed/19074198 http://dx.doi.org/10.1093/nar/gkn993

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