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The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans

BACKGROUND: There is accumulating evidence for a link between trauma exposure, posttraumatic stress disorder (PTSD) and diminished health status. To assess PTSD-related biological burden, we measured biological factors that comprise metabolic syndrome, an important established predictor of morbidity...

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Autores principales: Heppner, Pia S, Crawford, Eric F, Haji, Uzair A, Afari, Niloofar, Hauger, Richard L, Dashevsky, Boris A, Horn, Paul S, Nunnink, Sarah E, Baker, Dewleen G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647553/
https://www.ncbi.nlm.nih.gov/pubmed/19134183
http://dx.doi.org/10.1186/1741-7015-7-1
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author Heppner, Pia S
Crawford, Eric F
Haji, Uzair A
Afari, Niloofar
Hauger, Richard L
Dashevsky, Boris A
Horn, Paul S
Nunnink, Sarah E
Baker, Dewleen G
author_facet Heppner, Pia S
Crawford, Eric F
Haji, Uzair A
Afari, Niloofar
Hauger, Richard L
Dashevsky, Boris A
Horn, Paul S
Nunnink, Sarah E
Baker, Dewleen G
author_sort Heppner, Pia S
collection PubMed
description BACKGROUND: There is accumulating evidence for a link between trauma exposure, posttraumatic stress disorder (PTSD) and diminished health status. To assess PTSD-related biological burden, we measured biological factors that comprise metabolic syndrome, an important established predictor of morbidity and mortality, as a correlate of long-term health risk in PTSD. METHODS: We analyzed clinical data from 253 male and female veterans, corresponding to five factors linked to metabolic syndrome (systolic and diastolic blood pressure, waist-to-hip ratio and fasting measures of high-density lipoprotein (HDL) cholesterol, serum triglycerides and plasma glucose concentration). Clinical cut-offs were defined for each biological parameter based on recommendations from the World Health Organization and the National Cholesterol Education Program. Controlling for relevant variables including sociodemographic variables, alcohol/substance/nicotine use and depression, we examined the impact of PTSD on metabolic syndrome using a logistic regression model. RESULTS: Two-fifths (40%) of the sample met criteria for metabolic syndrome. Of those with PTSD (n = 139), 43% met criteria for metabolic syndrome. The model predicted metabolic syndrome well (-2 log likelihood = 316.650, chi-squared = 23.731, p = 0.005). Veterans with higher severity of PTSD were more likely to meet diagnostic criteria for metabolic syndrome (Wald = 4.76, p = 0.03). CONCLUSION: These findings provide preliminary evidence linking higher severity of PTSD with risk factors for diminished health and increased morbidity, as represented by metabolic syndrome.
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spelling pubmed-26475532009-02-25 The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans Heppner, Pia S Crawford, Eric F Haji, Uzair A Afari, Niloofar Hauger, Richard L Dashevsky, Boris A Horn, Paul S Nunnink, Sarah E Baker, Dewleen G BMC Med Research Article BACKGROUND: There is accumulating evidence for a link between trauma exposure, posttraumatic stress disorder (PTSD) and diminished health status. To assess PTSD-related biological burden, we measured biological factors that comprise metabolic syndrome, an important established predictor of morbidity and mortality, as a correlate of long-term health risk in PTSD. METHODS: We analyzed clinical data from 253 male and female veterans, corresponding to five factors linked to metabolic syndrome (systolic and diastolic blood pressure, waist-to-hip ratio and fasting measures of high-density lipoprotein (HDL) cholesterol, serum triglycerides and plasma glucose concentration). Clinical cut-offs were defined for each biological parameter based on recommendations from the World Health Organization and the National Cholesterol Education Program. Controlling for relevant variables including sociodemographic variables, alcohol/substance/nicotine use and depression, we examined the impact of PTSD on metabolic syndrome using a logistic regression model. RESULTS: Two-fifths (40%) of the sample met criteria for metabolic syndrome. Of those with PTSD (n = 139), 43% met criteria for metabolic syndrome. The model predicted metabolic syndrome well (-2 log likelihood = 316.650, chi-squared = 23.731, p = 0.005). Veterans with higher severity of PTSD were more likely to meet diagnostic criteria for metabolic syndrome (Wald = 4.76, p = 0.03). CONCLUSION: These findings provide preliminary evidence linking higher severity of PTSD with risk factors for diminished health and increased morbidity, as represented by metabolic syndrome. BioMed Central 2009-01-09 /pmc/articles/PMC2647553/ /pubmed/19134183 http://dx.doi.org/10.1186/1741-7015-7-1 Text en Copyright © 2009 Heppner et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Heppner, Pia S
Crawford, Eric F
Haji, Uzair A
Afari, Niloofar
Hauger, Richard L
Dashevsky, Boris A
Horn, Paul S
Nunnink, Sarah E
Baker, Dewleen G
The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans
title The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans
title_full The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans
title_fullStr The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans
title_full_unstemmed The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans
title_short The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans
title_sort association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647553/
https://www.ncbi.nlm.nih.gov/pubmed/19134183
http://dx.doi.org/10.1186/1741-7015-7-1
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