Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

The Hsc/Hsp70 co-chaperones of the BAG (Bcl-2-associated athanogene) protein family are modulators of protein quality control. We examined the specific roles of BAG1 and BAG3 in protein degradation during the aging process. We show that BAG1 and BAG3 regulate proteasomal and macroautophagic pathways...

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Detalles Bibliográficos
Autores principales: Gamerdinger, Martin, Hajieva, Parvana, Kaya, A Murat, Wolfrum, Uwe, Hartl, F Ulrich, Behl, Christian
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647772/
https://www.ncbi.nlm.nih.gov/pubmed/19229298
http://dx.doi.org/10.1038/emboj.2009.29

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647772/
https://www.ncbi.nlm.nih.gov/pubmed/19229298
http://dx.doi.org/10.1038/emboj.2009.29

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