Depletion of Kinesin 5B Affects Lysosomal Distribution and Stability and Induces Peri-Nuclear Accumulation of Autophagosomes in Cancer Cells

BACKGROUND: Enhanced lysosomal trafficking is associated with metastatic cancer. In an attempt to discover cancer relevant lysosomal motor proteins, we compared the lysosomal proteomes from parental MCF-7 breast cancer cells with those from highly invasive MCF-7 cells that express an active form of...

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Detalles Bibliográficos
Autores principales: Cardoso, Carla M. P., Groth-Pedersen, Line, Høyer-Hansen, Maria, Kirkegaard, Thomas, Corcelle, Elizabeth, Andersen, Jens S., Jäättelä, Marja, Nylandsted, Jesper
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647799/
https://www.ncbi.nlm.nih.gov/pubmed/19242560
http://dx.doi.org/10.1371/journal.pone.0004424

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