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Salmonella takes control: effector-driven manipulation of the host

Salmonella pathogenesis relies upon the delivery of over thirty specialised effector proteins into the host cell via two distinct type III secretion systems. These effectors act in concert to subvert the host cell cytoskeleton, signal transduction pathways, membrane trafficking and pro-inflammatory...

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Detalles Bibliográficos
Autores principales: McGhie, Emma J, Brawn, Lyndsey C, Hume, Peter J, Humphreys, Daniel, Koronakis, Vassilis
Formato: Texto
Lenguaje:English
Publicado: Current Biology 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647982/
https://www.ncbi.nlm.nih.gov/pubmed/19157959
http://dx.doi.org/10.1016/j.mib.2008.12.001
Descripción
Sumario:Salmonella pathogenesis relies upon the delivery of over thirty specialised effector proteins into the host cell via two distinct type III secretion systems. These effectors act in concert to subvert the host cell cytoskeleton, signal transduction pathways, membrane trafficking and pro-inflammatory responses. This allows Salmonella to invade non-phagocytic epithelial cells, establish and maintain an intracellular replicative niche and, in some cases, disseminate to cause systemic disease. This review focuses on the actions of the effectors on their host cell targets during each stage of Salmonella infection.