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The role of the pre-supplementary motor area in the control of action

Although regions within the medial frontal cortex are known to be active during voluntary movements their precise role remains unclear. Here we combine functional imaging localisation with psychophysics to demonstrate a strikingly selective contralesional impairment in the ability to inhibit ongoing...

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Detalles Bibliográficos
Autores principales: Nachev, Parashkev, Wydell, Henrietta, O’Neill, Kevin, Husain, Masud, Kennard, Christopher
Formato: Texto
Lenguaje:English
Publicado: Academic Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648723/
https://www.ncbi.nlm.nih.gov/pubmed/17499162
http://dx.doi.org/10.1016/j.neuroimage.2007.03.034
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author Nachev, Parashkev
Wydell, Henrietta
O’Neill, Kevin
Husain, Masud
Kennard, Christopher
author_facet Nachev, Parashkev
Wydell, Henrietta
O’Neill, Kevin
Husain, Masud
Kennard, Christopher
author_sort Nachev, Parashkev
collection PubMed
description Although regions within the medial frontal cortex are known to be active during voluntary movements their precise role remains unclear. Here we combine functional imaging localisation with psychophysics to demonstrate a strikingly selective contralesional impairment in the ability to inhibit ongoing movement plans in a patient with a rare lesion involving the right pre-supplementary motor area (pre-SMA), but sparing the supplementary motor area (SMA). We find no corresponding delay in simple reaction times, and show that the inhibitory deficit is sensitive to the presence of competition between responses. The findings demonstrate that the pre-SMA plays a critical role in exerting control over voluntary actions in situations of response conflict. We discuss these findings in the context of a unified framework of pre-SMA function, and explore the degree to which extant data on this region can be explained by this function alone.
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spelling pubmed-26487232009-02-27 The role of the pre-supplementary motor area in the control of action Nachev, Parashkev Wydell, Henrietta O’Neill, Kevin Husain, Masud Kennard, Christopher Neuroimage Article Although regions within the medial frontal cortex are known to be active during voluntary movements their precise role remains unclear. Here we combine functional imaging localisation with psychophysics to demonstrate a strikingly selective contralesional impairment in the ability to inhibit ongoing movement plans in a patient with a rare lesion involving the right pre-supplementary motor area (pre-SMA), but sparing the supplementary motor area (SMA). We find no corresponding delay in simple reaction times, and show that the inhibitory deficit is sensitive to the presence of competition between responses. The findings demonstrate that the pre-SMA plays a critical role in exerting control over voluntary actions in situations of response conflict. We discuss these findings in the context of a unified framework of pre-SMA function, and explore the degree to which extant data on this region can be explained by this function alone. Academic Press 2007 /pmc/articles/PMC2648723/ /pubmed/17499162 http://dx.doi.org/10.1016/j.neuroimage.2007.03.034 Text en © 2007 Elsevier Inc. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Nachev, Parashkev
Wydell, Henrietta
O’Neill, Kevin
Husain, Masud
Kennard, Christopher
The role of the pre-supplementary motor area in the control of action
title The role of the pre-supplementary motor area in the control of action
title_full The role of the pre-supplementary motor area in the control of action
title_fullStr The role of the pre-supplementary motor area in the control of action
title_full_unstemmed The role of the pre-supplementary motor area in the control of action
title_short The role of the pre-supplementary motor area in the control of action
title_sort role of the pre-supplementary motor area in the control of action
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648723/
https://www.ncbi.nlm.nih.gov/pubmed/17499162
http://dx.doi.org/10.1016/j.neuroimage.2007.03.034
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