A structural interpretation of the effect of GC-content on efficiency of RNA interference

BACKGROUND: RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) or short hairpin RNAs (shRNAs) has become a powerful technique for eukaryotic gene knockdown. siRNA GC-content negatively correlates with RNAi efficiency, and it is of interest to have a convincing mechanistic interpreta...

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Detalles Bibliográficos
Autores principales: Chan, Chi Yu, Carmack, C Steven, Long, Dang D, Maliyekkel, Anil, Shao, Yu, Roninson, Igor B, Ding, Ye
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648742/
https://www.ncbi.nlm.nih.gov/pubmed/19208134
http://dx.doi.org/10.1186/1471-2105-10-S1-S33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648742/
https://www.ncbi.nlm.nih.gov/pubmed/19208134
http://dx.doi.org/10.1186/1471-2105-10-S1-S33

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