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Role of Chromodomain Helicase DNA binding protein 2 in DNA damage response signaling and tumorigenesis

The chromodomain helicase DNA binding proteins (CHDs) are known to affect transcription via their ability to remodel chromatin and modulate histone deacetylation. In an effort to understand the functional role of the chromodomain helicase DNA binding protein 2 (CHD2) in mammals, we have generated Ch...

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Autores principales: Nagarajan, Prabakaran, Onami, Thandi M., Rajagopalan, Sangeetha, Kania, Stephen, Donnell, Robert, Venkatachalam, Sundaresan
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648865/
https://www.ncbi.nlm.nih.gov/pubmed/19137022
http://dx.doi.org/10.1038/onc.2008.440
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author Nagarajan, Prabakaran
Onami, Thandi M.
Rajagopalan, Sangeetha
Kania, Stephen
Donnell, Robert
Venkatachalam, Sundaresan
author_facet Nagarajan, Prabakaran
Onami, Thandi M.
Rajagopalan, Sangeetha
Kania, Stephen
Donnell, Robert
Venkatachalam, Sundaresan
author_sort Nagarajan, Prabakaran
collection PubMed
description The chromodomain helicase DNA binding proteins (CHDs) are known to affect transcription via their ability to remodel chromatin and modulate histone deacetylation. In an effort to understand the functional role of the chromodomain helicase DNA binding protein 2 (CHD2) in mammals, we have generated Chd2 mutant mouse model. Remarkably, the Chd2 protein appears to play a critical role in development, hematopoiesis, and tumor suppression. The Chd2 heterozygous mutant mice exhibit increased extra-medullary hematopoiesis and susceptibility to lymphomas. At the cellular level, Chd2 mutants are defective in hematopoietic stem cell differentiation, accumulate higher levels of the chromatin associated DNA damage response mediator, γH2AX, and exhibit an aberrant DNA damage response after X-ray irradiation. Our data suggest a direct role for the chromatin remodeling protein in DNA damage signaling and genome stability maintenance.
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spelling pubmed-26488652009-08-26 Role of Chromodomain Helicase DNA binding protein 2 in DNA damage response signaling and tumorigenesis Nagarajan, Prabakaran Onami, Thandi M. Rajagopalan, Sangeetha Kania, Stephen Donnell, Robert Venkatachalam, Sundaresan Oncogene Article The chromodomain helicase DNA binding proteins (CHDs) are known to affect transcription via their ability to remodel chromatin and modulate histone deacetylation. In an effort to understand the functional role of the chromodomain helicase DNA binding protein 2 (CHD2) in mammals, we have generated Chd2 mutant mouse model. Remarkably, the Chd2 protein appears to play a critical role in development, hematopoiesis, and tumor suppression. The Chd2 heterozygous mutant mice exhibit increased extra-medullary hematopoiesis and susceptibility to lymphomas. At the cellular level, Chd2 mutants are defective in hematopoietic stem cell differentiation, accumulate higher levels of the chromatin associated DNA damage response mediator, γH2AX, and exhibit an aberrant DNA damage response after X-ray irradiation. Our data suggest a direct role for the chromatin remodeling protein in DNA damage signaling and genome stability maintenance. 2009-01-12 2009-02-26 /pmc/articles/PMC2648865/ /pubmed/19137022 http://dx.doi.org/10.1038/onc.2008.440 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Nagarajan, Prabakaran
Onami, Thandi M.
Rajagopalan, Sangeetha
Kania, Stephen
Donnell, Robert
Venkatachalam, Sundaresan
Role of Chromodomain Helicase DNA binding protein 2 in DNA damage response signaling and tumorigenesis
title Role of Chromodomain Helicase DNA binding protein 2 in DNA damage response signaling and tumorigenesis
title_full Role of Chromodomain Helicase DNA binding protein 2 in DNA damage response signaling and tumorigenesis
title_fullStr Role of Chromodomain Helicase DNA binding protein 2 in DNA damage response signaling and tumorigenesis
title_full_unstemmed Role of Chromodomain Helicase DNA binding protein 2 in DNA damage response signaling and tumorigenesis
title_short Role of Chromodomain Helicase DNA binding protein 2 in DNA damage response signaling and tumorigenesis
title_sort role of chromodomain helicase dna binding protein 2 in dna damage response signaling and tumorigenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648865/
https://www.ncbi.nlm.nih.gov/pubmed/19137022
http://dx.doi.org/10.1038/onc.2008.440
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