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Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M(1 )vs M(2 )muscarinic acetylcholine receptors

BACKGROUND: Sustained agonist-promoted ubiquitination of β-arrestin has been correlated with increased stability of the GPCR – β-arrestin complex. Moreover, abrogation of β-arrestin ubiquitination has been reported to inhibit receptor internalization with minimal effects on receptor degradation. RES...

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Detalles Bibliográficos
Autores principales:	Mosser, Valerie A, Jones, Kymry T, Hoffman, Katie M, McCarty, Nael A, Jackson, Darrell A
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648954/ https://www.ncbi.nlm.nih.gov/pubmed/19055777 http://dx.doi.org/10.1186/1750-2187-3-20

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