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A reason why the ERBB2 gene is amplified and not mutated in breast cancer
Alterations of receptor-type tyrosine kinases (RTK) are frequent in human cancers. They can result from translocation, mutation or amplification. The ERBB2 RTK is encoded by a gene that is amplified in about 20% breast cancers. The question is: why is this RTK specifically subjected to this type of...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649042/ https://www.ncbi.nlm.nih.gov/pubmed/19226453 http://dx.doi.org/10.1186/1475-2867-9-5 |