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Crystal Structure of Procaspase-1 Zymogen Domain Reveals Insight into Inflammatory Caspase Autoactivation

One key event in inflammatory signaling is the activation of the initiator caspase, procaspase-1. Presented here is the crystal structure of the procaspase-1 zymogen without its caspase recruitment domain solved to 2.05 Å. Although the isolated domain is monomeric in solution, the protein appeared d...

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Detalles Bibliográficos
Autores principales:	Elliott, J. Michael, Rouge, Lionel, Wiesmann, Christian, Scheer, Justin M.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Enzyme Catalysis and Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649088/ https://www.ncbi.nlm.nih.gov/pubmed/19117953 http://dx.doi.org/10.1074/jbc.M806121200

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