Cargando…

Crystal Structure of Procaspase-1 Zymogen Domain Reveals Insight into Inflammatory Caspase Autoactivation

One key event in inflammatory signaling is the activation of the initiator caspase, procaspase-1. Presented here is the crystal structure of the procaspase-1 zymogen without its caspase recruitment domain solved to 2.05 Å. Although the isolated domain is monomeric in solution, the protein appeared d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elliott, J. Michael, Rouge, Lionel, Wiesmann, Christian, Scheer, Justin M.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Enzyme Catalysis and Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649088/ https://www.ncbi.nlm.nih.gov/pubmed/19117953 http://dx.doi.org/10.1074/jbc.M806121200

Ejemplares similares

Connection Domain Mutations N348I and A360V in HIV-1 Reverse Transcriptase Enhance Resistance to 3′-Azido-3′-deoxythymidine through Both RNase H-dependent and -independent Mechanisms
por: Ehteshami, Maryam, et al.
Publicado: (2008)

Chemical Validation of Trypanothione Synthetase: A POTENTIAL DRUG TARGET FOR HUMAN TRYPANOSOMIASIS
por: Torrie, Leah S., et al.
Publicado: (2009)

Analysis of Nucleotide Binding to P97 Reveals the Properties of a Tandem AAA Hexameric ATPase
por: Briggs, Louise C., et al.
Publicado: (2008)

A Parasite Cysteine Protease Is Key to Host Protein Degradation and Iron Acquisition
por: O'Brien, Theresa C., et al.
Publicado: (2008)

Hepatitis C Viral NS3-4A Protease Activity Is Enhanced by the NS3 Helicase
por: Beran, Rudolf K. F., et al.
Publicado: (2008)

Bioactivation of Nitroglycerin by Purified Mitochondrial and Cytosolic Aldehyde Dehydrogenases
por: Beretta, Matteo, et al.
Publicado: (2008)

Leishmania Trypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities
por: Fyfe, Paul K., et al.
Publicado: (2008)

Partially Irreversible Inactivation of Mitochondrial Aldehyde Dehydrogenase by Nitroglycerin
por: Beretta, Matteo, et al.
Publicado: (2008)

Mutation of a Critical Arginine in Microsomal Prostaglandin E Synthase-1 Shifts the Isomerase Activity to a Reductase Activity That Converts Prostaglandin H(2) into Prostaglandin F(2α)
por: Hammarberg, Tove, et al.
Publicado: (2009)

Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)
por: Finn, Robert D., et al.
Publicado: (2008)

Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase
por: Baron, Rudi A., et al.
Publicado: (2009)

Selective Inhibition of Carotenoid Cleavage Dioxygenases: PHENOTYPIC EFFECTS ON SHOOT BRANCHING
por: Sergeant, Martin J., et al.
Publicado: (2009)

Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (Activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets
por: Du, Xiao-Yan, et al.
Publicado: (2009)

Instability of Superoxide Dismutase 1 of Drosophila in Mutants Deficient for Its Cognate Copper Chaperone
por: Kirby, Kim, et al.
Publicado: (2008)

Nicastrin Is Dispensable for γ-Secretase Protease Activity in the Presence of Specific Presenilin Mutations
por: Futai, Eugene, et al.
Publicado: (2009)

Biochemical, Functional, and Pharmacological Characterization of AT-56, an Orally Active and Selective Inhibitor of Lipocalin-type Prostaglandin D Synthase
por: Irikura, Daisuke, et al.
Publicado: (2009)

Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds
por: Lee, Cheng-Chung, et al.
Publicado: (2009)

Characterization and Inhibition of a Class II Diterpene Cyclase from Mycobacterium tuberculosis: IMPLICATIONS FOR TUBERCULOSIS
por: Mann, Francis M., et al.
Publicado: (2009)

Drug Effect Unveils Inter-head Cooperativity and Strain-dependent ADP Release in Fast Skeletal Actomyosin
por: Albet-Torres, Nuria, et al.
Publicado: (2009)

The Effects of Nitroxyl (HNO) on Soluble Guanylate Cyclase Activity: INTERACTIONS AT FERROUS HEME AND CYSTEINE THIOLS
por: Miller, Thomas W., et al.
Publicado: (2009)

Porphyrins Promote the Association of GENOMES UNCOUPLED 4 and a Mg-chelatase Subunit with Chloroplast Membranes
por: Adhikari, Neil D., et al.
Publicado: (2009)

Heme Regulatory Motifs in Heme Oxygenase-2 Form a Thiol/Disulfide Redox Switch That Responds to the Cellular Redox State
por: Yi, Li, et al.
Publicado: (2009)

Role of the General Base Glu-268 in Nitroglycerin Bioactivation and Superoxide Formation by Aldehyde Dehydrogenase-2
por: Wenzl, M. Verena, et al.
Publicado: (2009)

Global Consequences of Activation Loop Phosphorylation on Protein Kinase A
por: Steichen, Jon M., et al.
Publicado: (2010)

Characterization of the East Asian Variant of Aldehyde Dehydrogenase-2: BIOACTIVATION OF NITROGLYCERIN AND EFFECTS OF Alda-1
por: Beretta, Matteo, et al.
Publicado: (2010)

The Significance of EXDD and RXKD Motif Conservation in Rel Proteins
por: Sajish, Mathew, et al.
Publicado: (2009)

Properties of the Thioredoxin Fold Superfamily Are Modulated by a Single Amino Acid Residue
por: Ren, Guoping, et al.
Publicado: (2009)

Arabidopsis GH3.12 (PBS3) Conjugates Amino Acids to 4-Substituted Benzoates and Is Inhibited by Salicylate
por: Okrent, Rachel A., et al.
Publicado: (2009)

Time-dependent Autoinactivation of Phospho-Thr(286)-αCa(2+)/Calmodulin-dependent Protein Kinase II
por: Jama, Abdirahman M., et al.
Publicado: (2009)

Structure-based Mechanism of ADP-ribosylation by Sirtuins
por: Hawse, William F., et al.
Publicado: (2009)

SufA of the Opportunistic Pathogen Finegoldia magna Modulates Actions of the Antibacterial Chemokine MIG/CXCL9, Promoting Bacterial Survival during Epithelial Inflammation
por: Karlsson, Christofer, et al.
Publicado: (2009)

A Biosensor for Fluorescent Determination of ADP with High Time Resolution
por: Kunzelmann, Simone, et al.
Publicado: (2009)

Role of Bacillus subtilis BacB in the Synthesis of Bacilysin
por: Rajavel, Malligarjunan, et al.
Publicado: (2009)

Biosynthesis, Purification, and Substrate Specificity of Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase
por: Fan, Keqiang, et al.
Publicado: (2004)

The Nucleocapsid Protein of Severe Acute Respiratory Syndrome-Coronavirus Inhibits the Activity of Cyclin-Cyclin-dependent Kinase Complex and Blocks S Phase Progression in Mammalian Cells
por: Surjit, Milan, et al.
Publicado: (2006)

SARS Coronavirus, but Not Human Coronavirus NL63, Utilizes Cathepsin L to Infect ACE2-expressing Cells
por: Huang, I-Chueh, et al.
Publicado: (2006)

Plasminogen Activator Inhibitor-1 Is an Inhibitor of Factor VII-activating Protease in Patients with Acute Respiratory Distress Syndrome
por: Wygrecka, Malgorzata, et al.
Publicado: (2007)

Only One Protomer Is Active in the Dimer of SARS 3C-like Proteinase
por: Chen, Hao, et al.
Publicado: (2006)

Critical Assessment of Important Regions in the Subunit Association and Catalytic Action of the Severe Acute Respiratory Syndrome Coronavirus Main Protease
por: Hsu, Wen-Chi, et al.
Publicado: (2005)

The Severe Acute Respiratory Syndrome (SARS) Coronavirus NTPase/Helicase Belongs to a Distinct Class of 5′ to 3′ Viral Helicases
por: Tanner, Julian A., et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_g2fc23aa9cf4l63i3b5mbt2dgt