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Novel point mutations attenuate autotaxin activity

BACKGROUND: The secreted enzyme autotaxin (ATX) stimulates tumor cell migration, tumorigenesis, angiogenesis, and metastasis. ATX hydrolyzes nucleotides, but its hydrolysis of lysophospholipids to produce lysophosphatidic acid (LPA) accounts for its biological activities. ATX has been identified onl...

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Detalles Bibliográficos
Autores principales:	Koh, Eunjin, Bandle, Russell W, Roberts, David D, Stracke, Mary L, Clair, Timothy
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649126/ https://www.ncbi.nlm.nih.gov/pubmed/19222837 http://dx.doi.org/10.1186/1476-511X-8-4

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