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Two mechanisms of the enhanced antibody-dependent cellular cytotoxicity (ADCC) efficacy of non-fucosylated therapeutic antibodies in human blood

BACKGROUND: Antibody-dependent cellular cytotoxicity (ADCC) has recently been identified as one of the critical mechanisms underlying the clinical efficacy of therapeutic antibodies, especially anticancer antibodies. Therapeutic antibodies fully lacking the core fucose of the Fc oligosaccharides hav...

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Detalles Bibliográficos
Autores principales:	Iida, Shigeru, Kuni-Kamochi, Reiko, Mori, Katsuhiro, Misaka, Hirofumi, Inoue, Miho, Okazaki, Akira, Shitara, Kenya, Satoh, Mitsuo
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649154/ https://www.ncbi.nlm.nih.gov/pubmed/19226457 http://dx.doi.org/10.1186/1471-2407-9-58

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