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A Hydrogen Bond in Loop A Is Critical for the Binding and Function of the 5-HT(3) Receptor
[Image: see text] The binding sites of Cys-loop receptors are formed from at least six loops (A−F). Here we have used mutagenesis, radioligand binding, voltage clamp electrophysiology, and homology modeling to probe the role of two residues in loop A of the 5-HT(3) receptor: Asn128 and Glu129. The d...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649372/ https://www.ncbi.nlm.nih.gov/pubmed/18498149 http://dx.doi.org/10.1021/bi800222n |