Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones – A practical synthesis of monastrol

A zeolite-catalyzed, simple, one-pot, solvent-free, cost effective, and environmentally benign process for the synthesis of dihydropyrimidones is described. This reaction is scaleable to multigram scale and the catalyst is recyclable. This methodology has resulted in an efficient synthesis of monast...

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Autores principales: Kulkarni, Mukund G, Chavhan, Sanjay W, Shinde, Mahadev P, Gaikwad, Dnyaneshwar D, Borhade, Ajit S, Dhondge, Attrimuni P, Shaikh, Yunnus B, Ningdale, Vijay B, Desai, Mayur P, Birhade, Deekshaputra R
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2009
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649439/
https://www.ncbi.nlm.nih.gov/pubmed/19259340
http://dx.doi.org/10.3762/bjoc.5.4
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author Kulkarni, Mukund G
Chavhan, Sanjay W
Shinde, Mahadev P
Gaikwad, Dnyaneshwar D
Borhade, Ajit S
Dhondge, Attrimuni P
Shaikh, Yunnus B
Ningdale, Vijay B
Desai, Mayur P
Birhade, Deekshaputra R
author_facet Kulkarni, Mukund G
Chavhan, Sanjay W
Shinde, Mahadev P
Gaikwad, Dnyaneshwar D
Borhade, Ajit S
Dhondge, Attrimuni P
Shaikh, Yunnus B
Ningdale, Vijay B
Desai, Mayur P
Birhade, Deekshaputra R
author_sort Kulkarni, Mukund G
collection PubMed
description A zeolite-catalyzed, simple, one-pot, solvent-free, cost effective, and environmentally benign process for the synthesis of dihydropyrimidones is described. This reaction is scaleable to multigram scale and the catalyst is recyclable. This methodology has resulted in an efficient synthesis of monastrol, a potent inhibitor of kinesin Eg5.
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spelling pubmed-26494392009-03-03 Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones – A practical synthesis of monastrol Kulkarni, Mukund G Chavhan, Sanjay W Shinde, Mahadev P Gaikwad, Dnyaneshwar D Borhade, Ajit S Dhondge, Attrimuni P Shaikh, Yunnus B Ningdale, Vijay B Desai, Mayur P Birhade, Deekshaputra R Beilstein J Org Chem Preliminary Communication A zeolite-catalyzed, simple, one-pot, solvent-free, cost effective, and environmentally benign process for the synthesis of dihydropyrimidones is described. This reaction is scaleable to multigram scale and the catalyst is recyclable. This methodology has resulted in an efficient synthesis of monastrol, a potent inhibitor of kinesin Eg5. Beilstein-Institut 2009-02-04 /pmc/articles/PMC2649439/ /pubmed/19259340 http://dx.doi.org/10.3762/bjoc.5.4 Text en Copyright © 2009, Kulkarni et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Preliminary Communication
Kulkarni, Mukund G
Chavhan, Sanjay W
Shinde, Mahadev P
Gaikwad, Dnyaneshwar D
Borhade, Ajit S
Dhondge, Attrimuni P
Shaikh, Yunnus B
Ningdale, Vijay B
Desai, Mayur P
Birhade, Deekshaputra R
Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones – A practical synthesis of monastrol
title Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones – A practical synthesis of monastrol
title_full Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones – A practical synthesis of monastrol
title_fullStr Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones – A practical synthesis of monastrol
title_full_unstemmed Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones – A practical synthesis of monastrol
title_short Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones – A practical synthesis of monastrol
title_sort zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1h)-ones – a practical synthesis of monastrol
topic Preliminary Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649439/
https://www.ncbi.nlm.nih.gov/pubmed/19259340
http://dx.doi.org/10.3762/bjoc.5.4
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