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Feasibility investigation of allogeneic endometrial regenerative cells

Endometrial Regenerative Cells (ERC) are a population of mesenchymal-like stem cells having pluripotent differentiation activity and ability to induce neoangiogenesis. In vitro and animal studies suggest ERC are immune privileged and in certain situations actively suppress ongoing immune responses....

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Autores principales: Zhong, Zhaohui, Patel, Amit N, Ichim, Thomas E, Riordan, Neil H, Wang, Hao, Min, Wei-Ping, Woods, Erik J, Reid, Michael, Mansilla, Eduardo, Marin, Gustavo H, Drago, Hugo, Murphy, Michael P, Minev, Boris
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649897/
https://www.ncbi.nlm.nih.gov/pubmed/19232091
http://dx.doi.org/10.1186/1479-5876-7-15
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author Zhong, Zhaohui
Patel, Amit N
Ichim, Thomas E
Riordan, Neil H
Wang, Hao
Min, Wei-Ping
Woods, Erik J
Reid, Michael
Mansilla, Eduardo
Marin, Gustavo H
Drago, Hugo
Murphy, Michael P
Minev, Boris
author_facet Zhong, Zhaohui
Patel, Amit N
Ichim, Thomas E
Riordan, Neil H
Wang, Hao
Min, Wei-Ping
Woods, Erik J
Reid, Michael
Mansilla, Eduardo
Marin, Gustavo H
Drago, Hugo
Murphy, Michael P
Minev, Boris
author_sort Zhong, Zhaohui
collection PubMed
description Endometrial Regenerative Cells (ERC) are a population of mesenchymal-like stem cells having pluripotent differentiation activity and ability to induce neoangiogenesis. In vitro and animal studies suggest ERC are immune privileged and in certain situations actively suppress ongoing immune responses. In this paper we describe the production of clinical grade ERC and initial safety experiences in 4 patients with multiple sclerosis treated intravenously and intrathecally. The case with the longest follow up, of more than one year, revealed no immunological reactions or treatment associated adverse effects. These preliminary data suggest feasibility of clinical ERC administration and support further studies with this novel stem cell type.
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spelling pubmed-26498972009-03-03 Feasibility investigation of allogeneic endometrial regenerative cells Zhong, Zhaohui Patel, Amit N Ichim, Thomas E Riordan, Neil H Wang, Hao Min, Wei-Ping Woods, Erik J Reid, Michael Mansilla, Eduardo Marin, Gustavo H Drago, Hugo Murphy, Michael P Minev, Boris J Transl Med Research Endometrial Regenerative Cells (ERC) are a population of mesenchymal-like stem cells having pluripotent differentiation activity and ability to induce neoangiogenesis. In vitro and animal studies suggest ERC are immune privileged and in certain situations actively suppress ongoing immune responses. In this paper we describe the production of clinical grade ERC and initial safety experiences in 4 patients with multiple sclerosis treated intravenously and intrathecally. The case with the longest follow up, of more than one year, revealed no immunological reactions or treatment associated adverse effects. These preliminary data suggest feasibility of clinical ERC administration and support further studies with this novel stem cell type. BioMed Central 2009-02-20 /pmc/articles/PMC2649897/ /pubmed/19232091 http://dx.doi.org/10.1186/1479-5876-7-15 Text en Copyright © 2009 Zhong et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Zhong, Zhaohui
Patel, Amit N
Ichim, Thomas E
Riordan, Neil H
Wang, Hao
Min, Wei-Ping
Woods, Erik J
Reid, Michael
Mansilla, Eduardo
Marin, Gustavo H
Drago, Hugo
Murphy, Michael P
Minev, Boris
Feasibility investigation of allogeneic endometrial regenerative cells
title Feasibility investigation of allogeneic endometrial regenerative cells
title_full Feasibility investigation of allogeneic endometrial regenerative cells
title_fullStr Feasibility investigation of allogeneic endometrial regenerative cells
title_full_unstemmed Feasibility investigation of allogeneic endometrial regenerative cells
title_short Feasibility investigation of allogeneic endometrial regenerative cells
title_sort feasibility investigation of allogeneic endometrial regenerative cells
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649897/
https://www.ncbi.nlm.nih.gov/pubmed/19232091
http://dx.doi.org/10.1186/1479-5876-7-15
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