Cargando…

Microglial inhibition of neuroprotection by antagonists of the EP1 prostaglandin E2 receptor

BACKGROUND: The EP1 receptor for the prostanoid PGE2 is a G-protein coupled receptor that has been shown to contribute to excitotoxic neuronal death. In this study we examined the influence of non-neuronal cells on neuroprotective properties of EP1 receptor antagonists (Ono 8711 and SC 51089). METHO...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carlson, Noel G, Rojas, Monica A, Black, John-David, Redd, Jonathan W, Hille, John, Hill, Kenneth E, Rose, John W
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649915/ https://www.ncbi.nlm.nih.gov/pubmed/19222857 http://dx.doi.org/10.1186/1742-2094-6-5

Ejemplares similares

The role of the prostaglandin E2 receptors in vulnerability of oligodendrocyte precursor cells to death
por: Carlson, Noel G., et al.
Publicado: (2015)

Cyclooxygenase-2 expression in oligodendrocytes increases sensitivity to excitotoxic death
por: Carlson, Noel G, et al.
Publicado: (2010)

Grapiprant: an EP4 prostaglandin receptor antagonist and novel therapy for pain and inflammation
por: Kirkby Shaw, Kristin, et al.
Publicado: (2015)

Prostaglandin E(2 )receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated α-synuclein
por: Jin, Jinghua, et al.
Publicado: (2007)

A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration
por: Jin, Yunyun, et al.
Publicado: (2022)

LY3127760, a Selective Prostaglandin E4 (EP4) Receptor Antagonist, and Celecoxib: A Comparison of Pharmacological Profiles
por: Jin, Yan, et al.
Publicado: (2017)

Steroidal Antagonists of Progesterone- and Prostaglandin E(1)-Induced Activation of the Cation Channel of Sperm
por: Carlson, Erick J., et al.
Publicado: (2022)

Role of EP(2) and EP(4) receptors in airway microvascular leak induced by prostaglandin E(2)
por: Jones, Victoria C, et al.
Publicado: (2016)

The role of the EP receptors for prostaglandin E(2) in skin and skin cancer
por: Rundhaug, J. E., et al.
Publicado: (2011)

Prostaglandin E receptor 4 (EP4) promotes colonic tumorigenesis
por: Chang, Jian, et al.
Publicado: (2015)

Prostaglandin E2/EP Signaling in the Tumor Microenvironment of Colorectal Cancer
por: Mizuno, Rei, et al.
Publicado: (2019)

Prostaglandin E2 receptor EP1 expression in vulvar cancer
por: Buchholz, Anna, et al.
Publicado: (2022)

Monocyte dysfunction in decompensated cirrhosis is mediated by the prostaglandin E2-EP4 pathway
por: Maini, Alexander A., et al.
Publicado: (2021)

The pharmacological effect of BGC20-1531, a novel prostanoid EP(4) receptor antagonist, in the Prostaglandin E(2) human model of headache
por: Antonova, Maria, et al.
Publicado: (2011)

Edition of Prostaglandin E2 Receptors EP2 and EP4 by CRISPR/Cas9 Technology in Equine Adipose Mesenchymal Stem Cells
por: Mançanares, Ana Carolina Furlanetto, et al.
Publicado: (2020)

Prostaglandin EP2 receptor antagonist ameliorates neuroinflammation in a two-hit mouse model of Alzheimer’s disease
por: Banik, Avijit, et al.
Publicado: (2021)

Role of the Prostaglandin E(2) EP1 Receptor in Traumatic Brain Injury
por: Glushakov, Alexander V., et al.
Publicado: (2014)

Heterodimerization of the prostaglandin E2 receptor EP2 and the calcitonin receptor CTR
por: Matsubara, Shin, et al.
Publicado: (2017)

Prostaglandin E2 promotes human CD34(+) cells homing through EP2 and EP4 in vitro
por: Wang, Yaqun, et al.
Publicado: (2017)

Concerted EP2 and EP4 Receptor Signaling Stimulates Autocrine Prostaglandin E(2) Activation in Human Podocytes
por: Mangelsen, Eva, et al.
Publicado: (2020)

A Novel Small Molecular Prostaglandin Receptor EP4 Antagonist, L001, Suppresses Pancreatic Cancer Metastasis
por: He, Jiacheng, et al.
Publicado: (2022)

Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1
por: Nagamachi, Miyako, et al.
Publicado: (2007)

A biological target for antiplatelet therapy: the prostaglandin E(2) receptor EP(4)
por: Philipose, Sonia, et al.
Publicado: (2010)

Prostaglandin E(2 )acts via the EP(4 )receptor to inhibit platelet aggregation
por: Philipose, Sonia, et al.
Publicado: (2009)

Opposing effects of prostaglandin E(2) receptors EP3 and EP4 on mouse and human β-cell survival and proliferation
por: Carboneau, Bethany A., et al.
Publicado: (2017)

Characterization of the Signaling Modalities of Prostaglandin E2 Receptors EP2 and EP4 Reveals Crosstalk and a Role for Microtubules
por: Vleeshouwers, Ward, et al.
Publicado: (2021)

Prostaglandin E Receptor 4 Antagonist in Cancer Immunotherapy: Mechanisms of Action
por: Take, Yukinori, et al.
Publicado: (2020)

Cloning and expression of the rabbit prostaglandin EP2 receptor
por: Guan, Youfei, et al.
Publicado: (2002)

Prostaglandin E(2) Prevents Hyperosmolar-Induced Human Mast Cell Activation through Prostanoid Receptors EP(2) and EP(4)
por: Torres-Atencio, Ivonne, et al.
Publicado: (2014)

T cell–intrinsic prostaglandin E(2)-EP2/EP4 signaling is critical in pathogenic T(H)17 cell–driven inflammation
por: Lee, Jinju, et al.
Publicado: (2019)

SYK coordinates neuroprotective microglial responses in neurodegenerative disease
por: Ennerfelt, Hannah, et al.
Publicado: (2022)

The Prostaglandin E2 Receptor EP4 Regulates Obesity-Related Inflammation and Insulin Sensitivity
por: Yasui, Mika, et al.
Publicado: (2015)

Prostaglandin E(2) receptor EP4 regulates cell migration through Orai1
por: Osawa, Kohei, et al.
Publicado: (2019)

A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE(2)-mediated immunosuppression and inhibits breast cancer metastasis
por: Ma, Xinrong, et al.
Publicado: (2013)

Biological effects of prostaglandin E2-EP4 antagonist (AAT-008) in murine colon cancer in vivo: enhancement of immune response to radiotherapy and potential as a radiosensitizer
por: Manabe, Yoshihiko, et al.
Publicado: (2023)

Regulation of prostaglandin EP(1) and EP(4) receptor signaling by carrier-mediated ligand reuptake
por: Chi, Yuling, et al.
Publicado: (2014)

Functional expression of human prostaglandin E2 receptor 4 (EP4) in E. coli and characterization of the binding property of EP4 with G(α) proteins
por: Kim, Nam Hyuk, et al.
Publicado: (2020)

Activation of calcitonin gene-related peptide signaling through the prostaglandin E2-EP1/EP2/EP4 receptor pathway in synovium of knee osteoarthritis patients
por: Minatani, Atsushi, et al.
Publicado: (2016)

Inhibitory effects of prostaglandin EP(4 )receptors on human eosinophils
por: Luschnig-Schratl, Petra, et al.
Publicado: (2009)

Role of prostaglandin E receptor subtypes EP2 and EP4 in autocrine and paracrine functions of vascular endothelial growth factor in the inner ear
por: Hori, Ryusuke, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_rg7mi9v3gj5svtvf56h222enit