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Identifying Critical Non-Catalytic Residues that Modulate Protein Kinase A Activity
BACKGROUND: Distal interactions between discrete elements of an enzyme are critical for communication and ultimately for regulation. However, identifying the components of such interactions has remained elusive due to the delicate nature of these contacts. Protein kinases are a prime example of an e...
Autores principales: | Kennedy, Eileen J., Yang, Jie, Pillus, Lorraine, Taylor, Susan S., Ghosh, Gourisankar |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650257/ https://www.ncbi.nlm.nih.gov/pubmed/19270744 http://dx.doi.org/10.1371/journal.pone.0004746 |
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