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TRAF6 Is Required for Generation of the B-1a B Cell Compartment as well as T Cell-Dependent and -Independent Humoral Immune Responses
TNF receptor superfamily members, such as CD40 and the Toll-like receptors (TLRs), regulate many aspects of B cell differentiation and activation. TRAF6 is an intracellular signaling adaptor molecule for these receptors, but its role in B cells has not been clarified by previous genetic approaches,...
Autores principales: | Kobayashi, Takashi, Kim, Tae Soo, Jacob, Anand, Walsh, Matthew C., Kadono, Yuho, Fuentes-Pananá, Ezequiel, Yoshioka, Tomoko, Yoshimura, Akihiko, Yamamoto, Masahiro, Kaisho, Tsuneyasu, Akira, Shizuo, Monroe, John G., Choi, Yongwon |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650412/ https://www.ncbi.nlm.nih.gov/pubmed/19270748 http://dx.doi.org/10.1371/journal.pone.0004736 |
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