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Association of chronic obstructive pulmonary disease and obstructive sleep apnea consequences

Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are two diseases that often coexist within an individual. This coexistence is known as overlap syndrome and is the result of chance rather than a pathophysiological link. Although there are claims of a very high...

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Autores principales: Zamarrón, Carlos, Paz, Vanesa García, Morete, Emilio, del Campo Matías, Felix
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650593/
https://www.ncbi.nlm.nih.gov/pubmed/19281082
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author Zamarrón, Carlos
Paz, Vanesa García
Morete, Emilio
del Campo Matías, Felix
author_facet Zamarrón, Carlos
Paz, Vanesa García
Morete, Emilio
del Campo Matías, Felix
author_sort Zamarrón, Carlos
collection PubMed
description Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are two diseases that often coexist within an individual. This coexistence is known as overlap syndrome and is the result of chance rather than a pathophysiological link. Although there are claims of a very high incidence of OSAS in COPD patients, recent studies report that it is similar to the general population. Overlap patients present sleep-disordered breathing associated to upper and lower airway obstruction and a reduction in respiratory drive. These patients present unique characteristics, which set them apart from either COPD or OSAS patients. COPD and OSAS are independent risk factors for cardiovascular events and their coexistence in overlap syndrome probably increases this risk. The mechanisms underlying cardiovascular risk are still unclear, but may involve systemic inflammation, endothelial dysfunction, and tonic elevation of sympathetic neural activity. The treatment of choice for overlap syndrome in stable patients is CPAP with supplemental oxygen for correction of upper airway obstructive episodes and hypoxemia during sleep.
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spelling pubmed-26505932009-05-04 Association of chronic obstructive pulmonary disease and obstructive sleep apnea consequences Zamarrón, Carlos Paz, Vanesa García Morete, Emilio del Campo Matías, Felix Int J Chron Obstruct Pulmon Dis Reviews Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are two diseases that often coexist within an individual. This coexistence is known as overlap syndrome and is the result of chance rather than a pathophysiological link. Although there are claims of a very high incidence of OSAS in COPD patients, recent studies report that it is similar to the general population. Overlap patients present sleep-disordered breathing associated to upper and lower airway obstruction and a reduction in respiratory drive. These patients present unique characteristics, which set them apart from either COPD or OSAS patients. COPD and OSAS are independent risk factors for cardiovascular events and their coexistence in overlap syndrome probably increases this risk. The mechanisms underlying cardiovascular risk are still unclear, but may involve systemic inflammation, endothelial dysfunction, and tonic elevation of sympathetic neural activity. The treatment of choice for overlap syndrome in stable patients is CPAP with supplemental oxygen for correction of upper airway obstructive episodes and hypoxemia during sleep. Dove Medical Press 2008-12 2008-12 /pmc/articles/PMC2650593/ /pubmed/19281082 Text en © 2008 Dove Medical Press Limited. All rights reserved
spellingShingle Reviews
Zamarrón, Carlos
Paz, Vanesa García
Morete, Emilio
del Campo Matías, Felix
Association of chronic obstructive pulmonary disease and obstructive sleep apnea consequences
title Association of chronic obstructive pulmonary disease and obstructive sleep apnea consequences
title_full Association of chronic obstructive pulmonary disease and obstructive sleep apnea consequences
title_fullStr Association of chronic obstructive pulmonary disease and obstructive sleep apnea consequences
title_full_unstemmed Association of chronic obstructive pulmonary disease and obstructive sleep apnea consequences
title_short Association of chronic obstructive pulmonary disease and obstructive sleep apnea consequences
title_sort association of chronic obstructive pulmonary disease and obstructive sleep apnea consequences
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650593/
https://www.ncbi.nlm.nih.gov/pubmed/19281082
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