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Complete Genome Sequence of Finegoldia magna, an Anaerobic Opportunistic Pathogen

Finegoldia magna (formerly Peptostreptococcus magnus), a member of the Gram-positive anaerobic cocci (GPAC), is a commensal bacterium colonizing human skin and mucous membranes. Moreover, it is also recognized as an opportunistic pathogen responsible for various infectious diseases. Here, we report...

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Autores principales: Goto, Takatsugu, Yamashita, Atsushi, Hirakawa, Hideki, Matsutani, Minenosuke, Todo, Kozo, Ohshima, Kenshiro, Toh, Hidehiro, Miyamoto, Kazuaki, Kuhara, Satoru, Hattori, Masahira, Shimizu, Tohru, Akimoto, Shigeru
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650633/
https://www.ncbi.nlm.nih.gov/pubmed/18263572
http://dx.doi.org/10.1093/dnares/dsm030
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author Goto, Takatsugu
Yamashita, Atsushi
Hirakawa, Hideki
Matsutani, Minenosuke
Todo, Kozo
Ohshima, Kenshiro
Toh, Hidehiro
Miyamoto, Kazuaki
Kuhara, Satoru
Hattori, Masahira
Shimizu, Tohru
Akimoto, Shigeru
author_facet Goto, Takatsugu
Yamashita, Atsushi
Hirakawa, Hideki
Matsutani, Minenosuke
Todo, Kozo
Ohshima, Kenshiro
Toh, Hidehiro
Miyamoto, Kazuaki
Kuhara, Satoru
Hattori, Masahira
Shimizu, Tohru
Akimoto, Shigeru
author_sort Goto, Takatsugu
collection PubMed
description Finegoldia magna (formerly Peptostreptococcus magnus), a member of the Gram-positive anaerobic cocci (GPAC), is a commensal bacterium colonizing human skin and mucous membranes. Moreover, it is also recognized as an opportunistic pathogen responsible for various infectious diseases. Here, we report the complete genome sequence of F. magna ATCC 29328. The genome consists of a 1 797 577 bp circular chromosome and an 189 163 bp plasmid (pPEP1). The metabolic maps constructed based on the genome information confirmed that most F. magna strains cannot ferment most sugars, except fructose, and have various aminopeptidase activities. Three homologs of albumin-binding protein, a known virulence factor useful for antiphagocytosis, are encoded on the chromosome, and one albumin-binding protein homolog is encoded on the plasmid. A unique feature of the genome is that F. magna encodes many sortase genes, of which substrates may be involved in bacterial pathogenesis, such as antiphagocytosis and adherence to the host cell. The plasmid pPEP1 encodes seven sortase and seven substrate genes, whereas the chromosome encodes four sortase and 19 substrate genes. These plasmid-encoded sortases may play important roles in the pathogenesis of F. magna by enriching the variety of cell wall anchored surface proteins.
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spelling pubmed-26506332009-04-13 Complete Genome Sequence of Finegoldia magna, an Anaerobic Opportunistic Pathogen Goto, Takatsugu Yamashita, Atsushi Hirakawa, Hideki Matsutani, Minenosuke Todo, Kozo Ohshima, Kenshiro Toh, Hidehiro Miyamoto, Kazuaki Kuhara, Satoru Hattori, Masahira Shimizu, Tohru Akimoto, Shigeru DNA Res Full Papers Finegoldia magna (formerly Peptostreptococcus magnus), a member of the Gram-positive anaerobic cocci (GPAC), is a commensal bacterium colonizing human skin and mucous membranes. Moreover, it is also recognized as an opportunistic pathogen responsible for various infectious diseases. Here, we report the complete genome sequence of F. magna ATCC 29328. The genome consists of a 1 797 577 bp circular chromosome and an 189 163 bp plasmid (pPEP1). The metabolic maps constructed based on the genome information confirmed that most F. magna strains cannot ferment most sugars, except fructose, and have various aminopeptidase activities. Three homologs of albumin-binding protein, a known virulence factor useful for antiphagocytosis, are encoded on the chromosome, and one albumin-binding protein homolog is encoded on the plasmid. A unique feature of the genome is that F. magna encodes many sortase genes, of which substrates may be involved in bacterial pathogenesis, such as antiphagocytosis and adherence to the host cell. The plasmid pPEP1 encodes seven sortase and seven substrate genes, whereas the chromosome encodes four sortase and 19 substrate genes. These plasmid-encoded sortases may play important roles in the pathogenesis of F. magna by enriching the variety of cell wall anchored surface proteins. Oxford University Press 2008-02 2008-02-07 /pmc/articles/PMC2650633/ /pubmed/18263572 http://dx.doi.org/10.1093/dnares/dsm030 Text en © The Author 2008. Kazusa DNA Research Institute
spellingShingle Full Papers
Goto, Takatsugu
Yamashita, Atsushi
Hirakawa, Hideki
Matsutani, Minenosuke
Todo, Kozo
Ohshima, Kenshiro
Toh, Hidehiro
Miyamoto, Kazuaki
Kuhara, Satoru
Hattori, Masahira
Shimizu, Tohru
Akimoto, Shigeru
Complete Genome Sequence of Finegoldia magna, an Anaerobic Opportunistic Pathogen
title Complete Genome Sequence of Finegoldia magna, an Anaerobic Opportunistic Pathogen
title_full Complete Genome Sequence of Finegoldia magna, an Anaerobic Opportunistic Pathogen
title_fullStr Complete Genome Sequence of Finegoldia magna, an Anaerobic Opportunistic Pathogen
title_full_unstemmed Complete Genome Sequence of Finegoldia magna, an Anaerobic Opportunistic Pathogen
title_short Complete Genome Sequence of Finegoldia magna, an Anaerobic Opportunistic Pathogen
title_sort complete genome sequence of finegoldia magna, an anaerobic opportunistic pathogen
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650633/
https://www.ncbi.nlm.nih.gov/pubmed/18263572
http://dx.doi.org/10.1093/dnares/dsm030
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