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EMP3 Overexpression in Primary Breast Carcinomas is not Associated with Epigenetic Aberrations

Epithelial membrane protein 3 (EMP3) is a trans-membrane signaling molecule with important roles in the regulation of apoptosis, differentiation and invasion of cancer cells, but the detailed is largely still unknown. We analyzed the mRNA levels and methylation statuses of EMP3 in 63 primary breast...

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Autores principales: Zhou, Wei, Jiang, Zheng, Li, Xingang, Xu, Fenghua, Liu, Yanbing, Wen, Peie, Kong, Li, Hou, Ming, Yu, Jinming
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650972/
https://www.ncbi.nlm.nih.gov/pubmed/19270820
http://dx.doi.org/10.3346/jkms.2009.24.1.97
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author Zhou, Wei
Jiang, Zheng
Li, Xingang
Xu, Fenghua
Liu, Yanbing
Wen, Peie
Kong, Li
Hou, Ming
Yu, Jinming
author_facet Zhou, Wei
Jiang, Zheng
Li, Xingang
Xu, Fenghua
Liu, Yanbing
Wen, Peie
Kong, Li
Hou, Ming
Yu, Jinming
author_sort Zhou, Wei
collection PubMed
description Epithelial membrane protein 3 (EMP3) is a trans-membrane signaling molecule with important roles in the regulation of apoptosis, differentiation and invasion of cancer cells, but the detailed is largely still unknown. We analyzed the mRNA levels and methylation statuses of EMP3 in 63 primary breast carcinomas and assessed their correlations with clinicopathologic variables. The expression of EMP3 mRNA in primary breast carcinomas was significantly higher than the expression of 20 normal breast tissues (p<10(-7)). EMP3 overexpression in breast carcinomas was significantly related to histological grade III (p=3.9×10(-7)), lymph node metastasis (p=0.003), and strong Her-2 expression (p=3.3×10(-6)). Hypermethylation frequencies of EMP3 were detected in 36.5% of breast carcinomas by methylation-specific polymerase chain reaction. However, no significant correlations were found between methylation status of EMP3 and mRNA expression levels as well as other clinical parameters. In conclusion, EMP3 may be a novel marker of tumor aggressiveness. Overexpression of EMP3 in primary breast carcinoma is not associated with DNA methylation.
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spelling pubmed-26509722009-03-06 EMP3 Overexpression in Primary Breast Carcinomas is not Associated with Epigenetic Aberrations Zhou, Wei Jiang, Zheng Li, Xingang Xu, Fenghua Liu, Yanbing Wen, Peie Kong, Li Hou, Ming Yu, Jinming J Korean Med Sci Original Article Epithelial membrane protein 3 (EMP3) is a trans-membrane signaling molecule with important roles in the regulation of apoptosis, differentiation and invasion of cancer cells, but the detailed is largely still unknown. We analyzed the mRNA levels and methylation statuses of EMP3 in 63 primary breast carcinomas and assessed their correlations with clinicopathologic variables. The expression of EMP3 mRNA in primary breast carcinomas was significantly higher than the expression of 20 normal breast tissues (p<10(-7)). EMP3 overexpression in breast carcinomas was significantly related to histological grade III (p=3.9×10(-7)), lymph node metastasis (p=0.003), and strong Her-2 expression (p=3.3×10(-6)). Hypermethylation frequencies of EMP3 were detected in 36.5% of breast carcinomas by methylation-specific polymerase chain reaction. However, no significant correlations were found between methylation status of EMP3 and mRNA expression levels as well as other clinical parameters. In conclusion, EMP3 may be a novel marker of tumor aggressiveness. Overexpression of EMP3 in primary breast carcinoma is not associated with DNA methylation. The Korean Academy of Medical Sciences 2009-02 2009-02-28 /pmc/articles/PMC2650972/ /pubmed/19270820 http://dx.doi.org/10.3346/jkms.2009.24.1.97 Text en Copyright © 2009 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Zhou, Wei
Jiang, Zheng
Li, Xingang
Xu, Fenghua
Liu, Yanbing
Wen, Peie
Kong, Li
Hou, Ming
Yu, Jinming
EMP3 Overexpression in Primary Breast Carcinomas is not Associated with Epigenetic Aberrations
title EMP3 Overexpression in Primary Breast Carcinomas is not Associated with Epigenetic Aberrations
title_full EMP3 Overexpression in Primary Breast Carcinomas is not Associated with Epigenetic Aberrations
title_fullStr EMP3 Overexpression in Primary Breast Carcinomas is not Associated with Epigenetic Aberrations
title_full_unstemmed EMP3 Overexpression in Primary Breast Carcinomas is not Associated with Epigenetic Aberrations
title_short EMP3 Overexpression in Primary Breast Carcinomas is not Associated with Epigenetic Aberrations
title_sort emp3 overexpression in primary breast carcinomas is not associated with epigenetic aberrations
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650972/
https://www.ncbi.nlm.nih.gov/pubmed/19270820
http://dx.doi.org/10.3346/jkms.2009.24.1.97
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