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β-Selection: Abundance of TCRβ(–)/γδ(–) CD44(–)CD25(–) (DN4) cells in the foetal thymus

Expression of TCRβ and pre-TCR signalling are essential for differentiation of CD4(–)CD8(–) double negative (DN) thymocytes to the CD4(+)CD8(+) double-positive (DP) stage. Thymocyte development in adult Rag1, Rag2 or TCRβδ-deficient mice is arrested at the DN3 stage leading to the assumption that pr...

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Detalles Bibliográficos
Autores principales:	Hager-Theodorides, Ariadne L, Rowbotham, Nicola J, Outram, Susan V, Dessens, Johannes T, Crompton, Tessa
Formato:	Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2007
Materias:	Molecular immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651467/ https://www.ncbi.nlm.nih.gov/pubmed/17273993 http://dx.doi.org/10.1002/eji.200636503

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