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Formation of DNA−Protein Cross-Links Between γ-Hydroxypropanodeoxyguanosine and EcoRI
[Image: see text] The toxicity of acrolein, an α,β-unsaturated aldehyde produced during lipid peroxidation, is attributable to its high reactivity toward DNA and cellular proteins. The major acrolein−DNA adduct, γ-hydroxypropano-2′-deoxyguanosine (γ-HOPdG), ring opens to form a reactive N(2)-oxoprop...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651693/ https://www.ncbi.nlm.nih.gov/pubmed/18690724 http://dx.doi.org/10.1021/tx800092g |