Discovery of novel triple helical DNA intercalators by an integrated virtual and actual screening platform

Virtual Screening is an increasingly attractive way to discover new small molecules with potential medicinal value. We introduce a novel strategy that integrates use of the molecular docking software Surflex with experimental validation by the method of competition dialysis. This integrated approach...

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Detalles Bibliográficos
Autores principales: Holt, Patrick A., Ragazzon, Patricia, Strekowski, Lucjan, Chaires, Jonathan B., Trent, John O.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651796/
https://www.ncbi.nlm.nih.gov/pubmed/19136469
http://dx.doi.org/10.1093/nar/gkn1043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651796/
https://www.ncbi.nlm.nih.gov/pubmed/19136469
http://dx.doi.org/10.1093/nar/gkn1043

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