Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription

Tumours and immortalized cells avoid telomere attrition by using either the ribonucleoprotein enzyme telomerase or a recombination-based alternative lengthening of telomeres (ALT) mechanism. Available evidence from mice suggests that the epigenetic state of the telomere may influence the mechanism o...

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Detalles Bibliográficos
Autores principales: Ng, Laura J., Cropley, Jennifer E., Pickett, Hilda A., Reddel, Roger R., Suter, Catherine M.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651807/
https://www.ncbi.nlm.nih.gov/pubmed/19129228
http://dx.doi.org/10.1093/nar/gkn1030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651807/
https://www.ncbi.nlm.nih.gov/pubmed/19129228
http://dx.doi.org/10.1093/nar/gkn1030

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