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Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells

BACKGROUND: The Akt/PKB family of kinases is frequently activated in human cancers, including oral squamous cell carcinoma (OSCC). Akt-induced epithelial-to-mesenchymal transition (EMT) involves downregulation of E-cadherin, which appears to result from upregulation of the transcription repressor Sn...

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Detalles Bibliográficos
Autores principales:	Hong, Kyoung-Ok, Kim, Ji-Hong, Hong, Ji-Soo, Yoon, Hye-Jung, Lee, Jae-Il, Hong, Sam-Pyo, Hong, Seong-Doo
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651854/ https://www.ncbi.nlm.nih.gov/pubmed/19243631 http://dx.doi.org/10.1186/1756-9966-28-28

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