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Comparative kinomics of human and chimpanzee reveal unique kinship and functional diversity generated by new domain combinations
BACKGROUND: Phosphorylation by protein kinases is a common event in many cellular processes. Further, many kinases perform specialized roles and are regulated by non-kinase domains tethered to kinase domain. Perturbation in the regulation of kinases leads to malignancy. We have identified and analys...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651890/ https://www.ncbi.nlm.nih.gov/pubmed/19105813 http://dx.doi.org/10.1186/1471-2164-9-625 |