RNA interference screening demystified

Genetic screens, where the effects of modifying gene function on cell behaviour are assessed in a systematic fashion, have for some time provided useful information to those interested in disease pathogenesis and treatment. Genetic screens exploiting the phenomenon of RNA interference (RNAi) are now...

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Detalles Bibliográficos
Autores principales: Lord, C J, Martin, S A, Ashworth, A
Formato: Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2009
Materias:
Demystified
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652024/
https://www.ncbi.nlm.nih.gov/pubmed/19126568
http://dx.doi.org/10.1136/jcp.2008.058735
Descripción
Sumario:Genetic screens, where the effects of modifying gene function on cell behaviour are assessed in a systematic fashion, have for some time provided useful information to those interested in disease pathogenesis and treatment. Genetic screens exploiting the phenomenon of RNA interference (RNAi) are now becoming commonplace. This article explains the different RNAi screen formats and describes some of the applications of RNAi screening that may be pertinent to the research pathologist.

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