Ability of SPI2 mutant of S. typhi to effectively induce antibody responses to the mucosal antigen enterotoxigenic E. coli heat labile toxin B subunit after oral delivery to humans

We have evaluated an oral vaccine based on an Salmonella enteric serovar typhi (S. typhi) Ty2 derivative TSB7 harboring deletion mutations in ssaV (SPI-2) and aroC together with a chromosomally integrated copy of eltB encoding the B subunit of enterotoxigenic Escherichia coli heat labile toxin (LT-B...

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Detalles Bibliográficos
Autores principales: Khan, S., Chatfield, S., Stratford, R., Bedwell, J., Bentley, M., Sulsh, S., Giemza, R., Smith, S., Bongard, E., Cosgrove, C.A., Johnson, J., Dougan, G., Griffin, G.E., Makin, J., Lewis, D.J.M.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652036/
https://www.ncbi.nlm.nih.gov/pubmed/17412462
http://dx.doi.org/10.1016/j.vaccine.2007.03.007

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