An African Ancestry-Specific Allele of CTLA4 Confers Protection against Rheumatoid Arthritis in African Americans

Cytotoxic T-lymphocyte associated protein 4 (CTLA4) is a negative regulator of T-cell proliferation. Polymorphisms in CTLA4 have been inconsistently associated with susceptibility to rheumatoid arthritis (RA) in populations of European ancestry but have not been examined in African Americans. The pr...

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Detalles Bibliográficos
Autores principales: Kelley, James M., Hughes, Laura B., Faggard, Jeffrey D., Danila, Maria I., Crawford, Monica H., Edberg, Yuanqing, Padilla, Miguel A., Tiwari, Hemant K., Westfall, Andrew O., Alarcón, Graciela S., Conn, Doyt L., Jonas, Beth L., Callahan, Leigh F., Smith, Edwin A., Brasington, Richard D., Allison, David B., Kimberly, Robert P., Moreland, Larry W., Edberg, Jeffrey C., Bridges, S. Louis
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652071/
https://www.ncbi.nlm.nih.gov/pubmed/19300490
http://dx.doi.org/10.1371/journal.pgen.1000424

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