The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERBβ

Heme is a ligand for the human nuclear receptors (NR) REV-ERBα and REV-ERBβ, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, inflammation, and cancer. Here we show that transcription rep...

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Detalles Bibliográficos
Autores principales: Pardee, Keith I, Xu, Xiaohui, Reinking, Jeff, Schuetz, Anja, Dong, Aiping, Liu, Suya, Zhang, Rongguang, Tiefenbach, Jens, Lajoie, Gilles, Plotnikov, Alexander N, Botchkarev, Alexey, Krause, Henry M, Edwards, Aled
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652392/
https://www.ncbi.nlm.nih.gov/pubmed/19243223
http://dx.doi.org/10.1371/journal.pbio.1000043

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