Diversity Synthesis of Complex Pyridines Yields a Probe of a Neurotrophic Signaling Pathway

[Image: see text] Recognizing the value of including complex pyridines in small-molecule screening collections, we developed a previously unexplored [2 + 2 + 2]-cycloaddition of silyl-tethered diynes with nitriles. The tether provides high regioselectivity, while the solvent THF allows catalytic CpC...

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Detalles Bibliográficos
Autores principales: Gray, B. Lawrence, Wang, Xiang, Brown, W. Colby, Kuai, Letian, Schreiber, Stuart L.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652409/
https://www.ncbi.nlm.nih.gov/pubmed/18510333
http://dx.doi.org/10.1021/ol8004936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652409/
https://www.ncbi.nlm.nih.gov/pubmed/18510333
http://dx.doi.org/10.1021/ol8004936

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