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Specific regulation of mRNA cap methylation by the c-Myc and E2F1 transcription factors
Methylation of the mRNA 5′ guanosine cap is essential for efficient gene expression. The 5′methyl cap binds to eIF4E, which is the first step in the recruitment of mRNA to the 40S ribosomal subunit. To investigate whether mRNA cap methylation is regulated in a gene-specific manner, we established a...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652438/ https://www.ncbi.nlm.nih.gov/pubmed/19137018 http://dx.doi.org/10.1038/onc.2008.463 |