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Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampin

BACKGROUND: Rifampin is a first line antituberculosis drug active against bacilli in logarithmic and stationary phase, which interferes with RNA synthesis by binding to bacterial RNA polymerase. Tubercle bacilli achieve resistance to rifampin by accumulation of mutations in a short-81 bp region of t...

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Detalles Bibliográficos
Autores principales:	Zaczek, Anna, Brzostek, Anna, Augustynowicz-Kopec, Ewa, Zwolska, Zofia, Dziadek, Jaroslaw
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652454/ https://www.ncbi.nlm.nih.gov/pubmed/19146699 http://dx.doi.org/10.1186/1471-2180-9-10

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