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Removal of Hsf4 leads to cataract development in mice through down-regulation of γS-crystallin and Bfsp expression

BACKGROUND: Heat-shock transcription factor 4 (HSF4) mutations are associated with autosomal dominant lamellar cataract and Marner cataract. Disruptions of the Hsf4 gene cause lens defects in mice, indicating a requirement for HSF4 in fiber cell differentiation during lens development. However, neit...

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Detalles Bibliográficos
Autores principales:	Shi, Xiaohe, Cui, Bin, Wang, Zhugang, Weng, Lin, Xu, Zhongping, Ma, Jinjin, Xu, Guotong, Kong, Xiangyin, Hu, Landian
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653017/ https://www.ncbi.nlm.nih.gov/pubmed/19224648 http://dx.doi.org/10.1186/1471-2199-10-10

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