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Blastocyst Injection of Wild Type Embryonic Stem Cells Induces Global Corrections in Mdx Mice

Duchenne muscular dystrophy (DMD) is an incurable neuromuscular degenerative disease, caused by a mutation in the dystrophin gene. Mdx mice recapitulate DMD features. Here we show that injection of wild-type (WT) embryonic stem cells (ESCs) into mdx blastocysts produces mice with improved pathology...

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Detalles Bibliográficos
Autores principales:	Stillwell, Elizabeth, Vitale, Joseph, Zhao, Qingshi, Beck, Amanda, Schneider, Joel, Khadim, Farah, Elson, Genie, Altaf, Aneela, Yehia, Ghassan, Dong, Jia-hui, Liu, Jing, Mark, Willie, Bhaumik, Mantu, Grange, Robert, Fraidenraich, Diego
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653195/ https://www.ncbi.nlm.nih.gov/pubmed/19277212 http://dx.doi.org/10.1371/journal.pone.0004759

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