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Regulation of multi-organ inflammation in the regulatory T cell-deficient scurfy mice

Scurfy mice display the most severe form of multi-organ inflammation due to total lack of the CD4(+)Foxp3(+ )regulatory T cells (Treg) resulted from a mutation of the X-linked transcription factor Foxp3. A large repertoire of Treg-suppressible, inflammation-inducing T cells was demonstrated by adopt...

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Detalles Bibliográficos
Autores principales: Sharma, Rahul, Sung, Sun-sang Joe, Fu, Shu Man, Ju, Shyr-Te
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653523/
https://www.ncbi.nlm.nih.gov/pubmed/19272184
http://dx.doi.org/10.1186/1423-0127-16-20