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Radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke
The aim of this study was to assess whether adjuvant treatment of breast cancer (BC) affects the risk of stroke, and to explore radiation targets and fraction doses regarding risk and location of stroke. In a Swedish BC cohort diagnosed during 1970–2003, we carried out a nested case–control study of...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653766/ https://www.ncbi.nlm.nih.gov/pubmed/19259096 http://dx.doi.org/10.1038/sj.bjc.6604902 |
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author | Nilsson, G Holmberg, L Garmo, H Terent, A Blomqvist, C |
author_facet | Nilsson, G Holmberg, L Garmo, H Terent, A Blomqvist, C |
author_sort | Nilsson, G |
collection | PubMed |
description | The aim of this study was to assess whether adjuvant treatment of breast cancer (BC) affects the risk of stroke, and to explore radiation targets and fraction doses regarding risk and location of stroke. In a Swedish BC cohort diagnosed during 1970–2003, we carried out a nested case–control study of stroke after BC, with relevant details extracted from medical records. The odds ratio (OR) for radiotherapy (RT) vs that of no RT did not differ between cases and controls (OR=0.85; confidence interval, CI=0.6–1.3). Radiotherapy to internal mammary chain (IMC) and supraclavicular (SCL) lymph nodes vs that of no RT was associated with a higher, although not statistically significant, risk of stroke (OR=1.3; CI=0.8–2.2). In a pooled analysis, RT to IMC and SCL vs the pooled group of no RT and RT to breast/chest wall/axilla (but not IMC and SCL), showed a significant increase of stroke (OR=1.8; CI=1.1–2.8). There were no associations between cancer laterality, targets of RT, and location of stroke. The radiation targets, IMC and SCL, showed a statistically significant trend for an increased risk of stroke with daily fraction dose. Our finding of a target-specific increased risk of stroke and a dose-response relationship for daily fraction dose, indicate that there may be a causal link between RT to the IMC and SCL and risk of stroke. |
format | Text |
id | pubmed-2653766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-26537662010-03-10 Radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke Nilsson, G Holmberg, L Garmo, H Terent, A Blomqvist, C Br J Cancer Epidemiology The aim of this study was to assess whether adjuvant treatment of breast cancer (BC) affects the risk of stroke, and to explore radiation targets and fraction doses regarding risk and location of stroke. In a Swedish BC cohort diagnosed during 1970–2003, we carried out a nested case–control study of stroke after BC, with relevant details extracted from medical records. The odds ratio (OR) for radiotherapy (RT) vs that of no RT did not differ between cases and controls (OR=0.85; confidence interval, CI=0.6–1.3). Radiotherapy to internal mammary chain (IMC) and supraclavicular (SCL) lymph nodes vs that of no RT was associated with a higher, although not statistically significant, risk of stroke (OR=1.3; CI=0.8–2.2). In a pooled analysis, RT to IMC and SCL vs the pooled group of no RT and RT to breast/chest wall/axilla (but not IMC and SCL), showed a significant increase of stroke (OR=1.8; CI=1.1–2.8). There were no associations between cancer laterality, targets of RT, and location of stroke. The radiation targets, IMC and SCL, showed a statistically significant trend for an increased risk of stroke with daily fraction dose. Our finding of a target-specific increased risk of stroke and a dose-response relationship for daily fraction dose, indicate that there may be a causal link between RT to the IMC and SCL and risk of stroke. Nature Publishing Group 2009-03-10 2009-03-03 /pmc/articles/PMC2653766/ /pubmed/19259096 http://dx.doi.org/10.1038/sj.bjc.6604902 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Epidemiology Nilsson, G Holmberg, L Garmo, H Terent, A Blomqvist, C Radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke |
title | Radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke |
title_full | Radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke |
title_fullStr | Radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke |
title_full_unstemmed | Radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke |
title_short | Radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke |
title_sort | radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653766/ https://www.ncbi.nlm.nih.gov/pubmed/19259096 http://dx.doi.org/10.1038/sj.bjc.6604902 |
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