The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome

RUNX3 is believed to have tumour suppressor properties in several cancer types. Inactivation of RUNX3 has been shown to occur by methylation-induced transcriptional silencing and by mislocalization of the protein to the cytoplasm. The aim of this study was to examine the clinical significance of RUN...

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Autores principales: Soong, R, Shah, N, Peh, B K, Chong, P Y, Ng, S S, Zeps, N, Joseph, D, Salto-Tellez, M, Iacopetta, B, Ito, Y
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653772/
https://www.ncbi.nlm.nih.gov/pubmed/19223906
http://dx.doi.org/10.1038/sj.bjc.6604899
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author Soong, R
Shah, N
Peh, B K
Chong, P Y
Ng, S S
Zeps, N
Joseph, D
Salto-Tellez, M
Iacopetta, B
Ito, Y
author_facet Soong, R
Shah, N
Peh, B K
Chong, P Y
Ng, S S
Zeps, N
Joseph, D
Salto-Tellez, M
Iacopetta, B
Ito, Y
author_sort Soong, R
collection PubMed
description RUNX3 is believed to have tumour suppressor properties in several cancer types. Inactivation of RUNX3 has been shown to occur by methylation-induced transcriptional silencing and by mislocalization of the protein to the cytoplasm. The aim of this study was to examine the clinical significance of RUNX3 expression in a large series of colorectal cancers using immunohistochemistry and tissue arrays. With advancing tumour stage, expression of RUNX3 in the nucleus decreased, whereas expression restricted to the cytoplasmic compartment increased. Nuclear RUNX3 expression was associated with significantly better patient survival compared to tumours in which the expression of RUNX3 was restricted to the cytoplasm (P=0.025). These results support a role for RUNX3 as a tumour suppressor in colorectal cancer.
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spelling pubmed-26537722010-03-10 The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome Soong, R Shah, N Peh, B K Chong, P Y Ng, S S Zeps, N Joseph, D Salto-Tellez, M Iacopetta, B Ito, Y Br J Cancer Clinical Study RUNX3 is believed to have tumour suppressor properties in several cancer types. Inactivation of RUNX3 has been shown to occur by methylation-induced transcriptional silencing and by mislocalization of the protein to the cytoplasm. The aim of this study was to examine the clinical significance of RUNX3 expression in a large series of colorectal cancers using immunohistochemistry and tissue arrays. With advancing tumour stage, expression of RUNX3 in the nucleus decreased, whereas expression restricted to the cytoplasmic compartment increased. Nuclear RUNX3 expression was associated with significantly better patient survival compared to tumours in which the expression of RUNX3 was restricted to the cytoplasm (P=0.025). These results support a role for RUNX3 as a tumour suppressor in colorectal cancer. Nature Publishing Group 2009-03-10 2009-02-17 /pmc/articles/PMC2653772/ /pubmed/19223906 http://dx.doi.org/10.1038/sj.bjc.6604899 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Clinical Study
Soong, R
Shah, N
Peh, B K
Chong, P Y
Ng, S S
Zeps, N
Joseph, D
Salto-Tellez, M
Iacopetta, B
Ito, Y
The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome
title The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome
title_full The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome
title_fullStr The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome
title_full_unstemmed The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome
title_short The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome
title_sort expression of runx3 in colorectal cancer is associated with disease stage and patient outcome
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653772/
https://www.ncbi.nlm.nih.gov/pubmed/19223906
http://dx.doi.org/10.1038/sj.bjc.6604899
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