Cargando…

Mechanism of Increased BK Channel Activation from a Channel Mutation that Causes Epilepsy

Concerted depolarization and Ca(2+) rise during neuronal action potentials activate large-conductance Ca(2+)- and voltage-dependent K(+) (BK) channels, whose robust K(+) currents increase the rate of action potential repolarization. Gain-of-function BK channels in mouse knockout of the inhibitory β4...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Bin, Rothberg, Brad S., Brenner, Robert
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654085/
https://www.ncbi.nlm.nih.gov/pubmed/19204188
http://dx.doi.org/10.1085/jgp.200810141