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Mechanism of Increased BK Channel Activation from a Channel Mutation that Causes Epilepsy
Concerted depolarization and Ca(2+) rise during neuronal action potentials activate large-conductance Ca(2+)- and voltage-dependent K(+) (BK) channels, whose robust K(+) currents increase the rate of action potential repolarization. Gain-of-function BK channels in mouse knockout of the inhibitory β4...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654085/ https://www.ncbi.nlm.nih.gov/pubmed/19204188 http://dx.doi.org/10.1085/jgp.200810141 |