Hexadecameric Self-Assembled Dendrimers Built from 2′-Deoxyguanosine Derivatives

[Image: see text] Herein we describe the construction of hexadecameric self-assembled dendrimers (SADs) using a series of dendronized 8-(m-acetylphenyl)-2′-deoxyguanosine (mAG) subunits. The azido-substituted mAG subunits were covalently linked to alkynyl polyester dendrons using a copper-catalyzed...

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Detalles Bibliográficos
Autores principales: Betancourt, José E., Rivera, José M.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654094/
https://www.ncbi.nlm.nih.gov/pubmed/18452304
http://dx.doi.org/10.1021/ol800701j
Descripción
Sumario:[Image: see text] Herein we describe the construction of hexadecameric self-assembled dendrimers (SADs) using a series of dendronized 8-(m-acetylphenyl)-2′-deoxyguanosine (mAG) subunits. The azido-substituted mAG subunits were covalently linked to alkynyl polyester dendrons using a copper-catalyzed 1,3-dipolar cycloaddition reaction. Discrete SADs are formed with high fidelity and thermal stability even with the increased steric hindrance offered by the dendrons.

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