PTCH1 (+/−) Dermal Fibroblasts Isolated from Healthy Skin of Gorlin Syndrome Patients Exhibit Features of Carcinoma Associated Fibroblasts

Gorlin's or nevoid basal cell carcinoma syndrome (NBCCS) causes predisposition to basal cell carcinoma (BCC), the commonest cancer in adult human. Mutations in the tumor suppressor gene PTCH1 are responsible for this autosomal dominant syndrome. In NBCCS patients, as in the general population,...

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Detalles Bibliográficos
Autores principales: Valin, Alexandre, Barnay-Verdier, Stéphanie, Robert, Thomas, Ripoche, Hugues, Brellier, Florence, Chevallier-Lagente, Odile, Avril, Marie-Françoise, Magnaldo, Thierry
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654107/
https://www.ncbi.nlm.nih.gov/pubmed/19287498
http://dx.doi.org/10.1371/journal.pone.0004818

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